VDR is a gene that encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene (rs2228570, FokI polymorphism) is associated with decreased bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by two components, and it is influenced gescheftmarketing.de/2023/08/28/how-to-manage-work-in-the-data-room/ through chromosomal sites and binding preferences for certain hormones. Microarray studies of human cells show that over 100 genes have an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online storage facility for data and documents related to legal, business transactions or other activities that have limitations on viewing or downloading. It uses a central server and an extranet connection which is an Internet connection that has restricted access, to provide controlled login times when users can view the data and documents.
VDRs are primarily used by investment banks and companies involved in mergers or acquisitions. They must be able to share information in a transparent way with potential investors or buyers. The due diligence process may also require a huge amount of data. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.
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